Steroids after spinal surgery

Discography, an invasive procedure, is performed using fluoroscopy (similar to x-ray, except in real time). To help you relax during the procedure, mild sedation may be administered. However, we cannot completely sedate, or put you to sleep, as you need to be alert enough to report what you feel to our team during the injection. An antibiotic may also be given intravenously before and after. You may be positioned, with pillows for support and comfort, on your side, or in another position. The injection sites are cleansed using an antiseptic and an anesthetic numbs the skin.

Eight trials are included in this review, seven used methylprednisolone. Methylprednisolone sodium succinate has been shown to improve neurologic outcome up to one year post-injury if administered within eight hours of injury and in a dose regimen of: bolus 30mg/kg over 15 minutes, with maintenance infusion of mg/kg per hour infused for 23 hours. The initial North American trial results were replicated in a Japanese trial but not in the one from France. Data was obtained from the latter studies to permit appropriate meta-analysis of all three trials. This indicated significant recovery in motor function after methylprednisolone therapy, when administration commenced within eight hours of injury. A more recent trial indicates that, if methylprednisolone therapy is given for an additional 24 hours (a total of 48 hours), additional improvement in motor neurologic function and functional status are observed. This is particularly observed if treatment cannot be started until between three to eight hours after injury. The same methylprednisolone therapy has been found effective in whiplash injuries. A modified regimen was found to improve recovery after surgery for lumbar disc disease. The risk of bias was low in the largest methyprednisolne trials. Overall, there was no evidence of significantly increased complications or mortality from the 23 or 48 hour therapy.

Scientists continue to investigate ways to better understand, diagnose, and treat CNS tumors.  Experimental treatment options may include new drugs,  gene therapy, surgery , radiation, biologic modulators that enhance the body's overall immune system to recognize and fight cancer cells, and a combination of therapies.  Of particular interest to scientists is the development of tailored therapeutics--involving a combination of targeted agents that use different molecules to reduce tumor gene activity and suppress uncontrolled growth by killing or reducing the production of tumor cells--to treat tumors based on their genetic makeup.  Researchers continue to search for additional clinical biomarkers (molecules or other substances in the blood or tissue that can be used to diagnose or monitor a particular disorder) of CNS tumors.  Other researchers are testing different drugs and molecules to see if they can modulate the normal activity of the blood-brain barrier and better target  tumor cells and associated blood vessels.  Also under investigation are ways to improve drug delivery to the tumor and to prevent the side-effects of cancer treatments.

Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:   20 Years to 70 Years   (Adult, Senior) Sexes Eligible for Study:   All Accepts Healthy Volunteers:   No Criteria Inclusion Criteria:

Steroids after spinal surgery

steroids after spinal surgery

Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:   20 Years to 70 Years   (Adult, Senior) Sexes Eligible for Study:   All Accepts Healthy Volunteers:   No Criteria Inclusion Criteria:

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