Renal syndromes associated with nonsteroidal antiinflammatory drugs

After surgical excision, up to 30% of patients with localized tumors experience relapse. The lung is the most common site of distant recurrence, seen in 50% to 60% of patients. The median time to relapse after surgery is approximately 2 years, with most relapses occurring within 5 years. Interferon alpha and high-dose interleukin-2 (IL-2) have been tested as adjuvant treatments following resection of stage 1-2 kidney cancer. However, no benefit has been seen in randomized trials. 29,30 Observation remains standard care after nephrectomy, and eligible patients should be offered enrollment in randomized clinical trials.

Although the kidney cannot directly sense blood, long-term regulation of blood pressure predominantly depends upon the kidney. This primarily occurs through maintenance of the extracellular fluid compartment, the size of which depends on the plasma sodium concentration. Renin is the first in a series of important chemical messengers that make up the renin-angiotensin system . Changes in renin ultimately alter the output of this system, principally the hormones angiotensin II and aldosterone . Each hormone acts via multiple mechanisms, but both increase the kidney's absorption of sodium chloride , thereby expanding the extracellular fluid compartment and raising blood pressure. When renin levels are elevated, the concentrations of angiotensin II and aldosterone increase, leading to increased sodium chloride reabsorption, expansion of the extracellular fluid compartment, and an increase in blood pressure. Conversely, when renin levels are low, angiotensin II and aldosterone levels decrease, contracting the extracellular fluid compartment, and decreasing blood pressure.

Q. experiencing sharp pain in my right kidney region... pain is acute and doesnt radiate... recently PE left lung have been taking warfrin, panadiene forte, two kinds of cholesterol/triglycerine reducing meds and champix quit smoking medication... recently tests showed the hight cholesterol and triglys' levels and also a swollen liver... pain is not in my liver area... past pain in this kidney recurrent but never as bad. always dull.. many years ago had a uti, which caused high protiene levels.. very bad at finishing anti-biotics... recently had tonsilitis.. This hurts and is tender to touch but does not bring on sharp pain when touched, sharp pain comes and goes after taking pain relief A. Go to see a doctor - although its tempting to make the diagnosis over the net (I have several ideas about what it might be), it sounds like serious, especially if you had a PE lately - it could be a thrombus in the vein of the kidney, or maybe a stone (sounds like that according to the description of the pain). However, as I said, making the diagnosis without even seeing you isn't the wisest thing to do.

Take care,

Overcoming Barriers to International Clinical Trials for Rare Cancers Friday, December 10, 2010
Location: Bethesda, Maryland Description: The goals of this conference were to introduce key institutional players to the topic of international clinical trials in rare cancers and to establish an ongoing dialogue. Participants left the meeting with a set of specific priorities that need to be enacted to promote these trials. The meeting promoted consensus on the way that resources are prioritized to address rare cancers. Participants were asked to convey the content of the meeting to their constituencies and to follow up with pilot concepts.

Renal syndromes associated with nonsteroidal antiinflammatory drugs

renal syndromes associated with nonsteroidal antiinflammatory drugs

Overcoming Barriers to International Clinical Trials for Rare Cancers Friday, December 10, 2010
Location: Bethesda, Maryland Description: The goals of this conference were to introduce key institutional players to the topic of international clinical trials in rare cancers and to establish an ongoing dialogue. Participants left the meeting with a set of specific priorities that need to be enacted to promote these trials. The meeting promoted consensus on the way that resources are prioritized to address rare cancers. Participants were asked to convey the content of the meeting to their constituencies and to follow up with pilot concepts.

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renal syndromes associated with nonsteroidal antiinflammatory drugsrenal syndromes associated with nonsteroidal antiinflammatory drugsrenal syndromes associated with nonsteroidal antiinflammatory drugsrenal syndromes associated with nonsteroidal antiinflammatory drugsrenal syndromes associated with nonsteroidal antiinflammatory drugs

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