Non-steroidal anti-inflammatory drugs for cancer prevention promise perils and pharmacogenetics

  • dose appropriately
  • pick the right drug and formulation?
    • Choose Cox-2 selective.
    • enteric coating (., aspirin) - a little protection, variable absorption
    • buffers (., aspirin) - a little protection, enhanced absorption
  • GI Protection?
    • PGE 2 analog - Misoprostol ® (Good evidence of efficacy)
    • Protectants (sucralfate) - no clear evidence
    • Omeprazole - no clear evidence
    • Cimetidine et al. - do not appear to be particularly effective for prevention.

Register for alerts
If you have registered for alerts, you should use your registered email address as your username

  • Citation tools Download this article to citation manager Day Richard O , Graham Garry G . Non-steroidal anti-inflammatory drugs (NSAIDs) BMJ 2013; 346 :f3195
    • BibTeX (win & mac) Download
    • EndNote (tagged) Download
    • EndNote 8 (xml) Download
    • RefWorks Tagged (win & mac) Download
    • RIS (win only) Download
    • Medlars Download
    Help If you are unable to import citations, please contact technical support for your product directly (links go to external sites):

    Six of the 13 included RCTs showed that NSAIDs are more effective than placebo regarding pain intensity. NSAIDs are slightly more effective than placebo regarding disability. However, the magnitude of the effects is small, and the level of evidence was low. When we only included RCTs at low risk of bias, differences in effect between NSAIDs and placebo were reduced. We identified no difference in efficacy between different NSAID types, including selective versus non-selective NSAIDs. Due to inclusion of RCTs only, the relatively small sample sizes and relatively short follow-up in most included trials, we cannot make firm statements about the occurrence of adverse events or whether NSAIDs are safe for long-term use.

    Non-steroidal anti-inflammatory drugs for cancer prevention promise perils and pharmacogenetics

    non-steroidal anti-inflammatory drugs for cancer prevention promise perils and pharmacogenetics

    Media:

    non-steroidal anti-inflammatory drugs for cancer prevention promise perils and pharmacogeneticsnon-steroidal anti-inflammatory drugs for cancer prevention promise perils and pharmacogeneticsnon-steroidal anti-inflammatory drugs for cancer prevention promise perils and pharmacogeneticsnon-steroidal anti-inflammatory drugs for cancer prevention promise perils and pharmacogeneticsnon-steroidal anti-inflammatory drugs for cancer prevention promise perils and pharmacogenetics

  • http://buy-steroids.org