Circumcision is the removal of the foreskin, either partially or completely. For newborns, it may be done for religious requirements or personal preferences surrounding hygiene and aesthetics.  :257 Circumcision may also be performed on children or adults to treat phimosis, balanitis, or to prevent transmission of sexually transmitted disease.  :166 As of 2012 no successful technique to reconstruct a circumsized foreskin had been published.  :181 Some men have used weights to stretch the skin of the penis to regrow a foreskin; the resulting tissue does cover the glans but does not replicate the features of a foreskin. 
Inadvertent exposure to the ubiquitous weed, Urtica dioica, called "stinging nettles" produces an immediate stinging and burning sensation on the skin. This investigation evaluates the structural effect that stinging nettle spicules may have on the clinical manifestation of these symptoms. This hypothesis was investigated by exposing murine skin to stinging nettles and then evaluating the skin using electron microscopy. It was hypothesized that the mechanism of action of stinging nettles is both biochemical and mechanical, which may have clinical significance regarding treatment for acute exposure.