Many men with Peyronie’s disease are anxious about the appearance of their penis, for obvious reasons. Some might feel worried about not being able to satisfy their partner or even fathering a child, due to difficulties having intercourse. The loss of intimacy and the relationship problems due to Peyronie’s disease can strongly affect one’s psychological well-being. [ 1,2 ] That is why it is important to be open about these feelings, however difficult it might be. Here are some tips/guidelines for talking to your partner about Peyronie’s disease.
Bleomycin (Blenoxane), a chemotherapeutic agent, inhibits DNA synthesis in cells and viruses. Bleomycin is an alternative therapy for warts that have not responded to other therapies or warts that may be difficult to surgically excise. Bleomycin comes in 15-unit vials; it typically is diluted with 30 mL of saline, and mL ( units) are injected into the wart. 6 Additional injections can be given every three to four weeks until clearance is achieved. 6 Pain is the major limiting factor to treatment. Potential side effects include scarring, change in pigmentation, nail damage, and Raynaud’s phenomenon. 4 , 21 Bleomycin is listed as pregnancy category D, given its potential for significant absorption following injection. 22 One study 23 examined the use of bleomycin for the treatment of recalcitrant warts. Following application of a topical anesthetic, bleomycin was placed on the wart and “pricked” into the wart using a needle. A clearance rate of 92 percent was observed. 23