Inhibidores de aromatasa no esteroideos

The structure of SMPI has been determined. It has 102 amino acid residues with two disulphide bridges and specifically inhibits metalloproteinases such as thermolysin , which belongs to MEROPS peptidase family M4. SMPI is composed of two beta-sheets , each consisting of four antiparallel beta-strands. The structure can be considered as two Greek key motifs with 2-fold internal symmetry, a Greek key beta-barrel . One unique structural feature found in SMPI is in its extension between the first and second strands of the second Greek key motif which is known to be involved in the inhibitory activity of SMPI. In the absence of sequence similarity, the SMPI structure shows clear similarity to both domains of the eye lens crystallins , both domains of the calcium sensor protein-S, as well as the single-domain yeast killer toxin . The yeast killer toxin structure was thought to be a precursor of the two-domain beta gamma-crystallin proteins, because of its structural similarity to each domain of the beta gamma-crystallins. SMPI thus provides another example of a single-domain protein structure that corresponds to the ancestral fold from which the two-domain proteins in the beta gamma-crystallin superfamily are believed to have evolved . [10]


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Este medicamento se utiliza solamente en la vagina. No lo ingiera por vía oral. Siga las instrucciones de la etiqueta del medicamento. Utilícelo a la hora de irse a dormir a menos que su médico o su profesional de la salud indique lo contrario. Utilice el aplicador especial suministrado con la crema. Lávese las manos antes y después de usar. Llene el aplicador con crema y retírelo del tubo. Recuéstese de espaldas, separe y flexione las rodillas. Introduzca el aplicador en la vagina y empuje el émbolo para llevar la crema dentro de la vagina. Lave el aplicador con agua caliente y jabón, y enjuáguelo bien. Utilícelo exactamente según se indica y durante todo el tiempo que fue recetada. No interrumpa su uso excepto si así lo indica su médico o su profesional de la salud.

Inhibidores de aromatasa no esteroideos

inhibidores de aromatasa no esteroideos

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