Sensitization dysbiosis refers to a condition where there is an increased immune response to the normal gut flora. This situation may be associated with the development of inflammatory bowel disease, spondyloarthropathies, other connective tissue disease and skin disorders like psoriasis or acne. One study at King's College, London, UK, found that IBD patients produced a higher than normal number of IgG antibodies in their intestines and that these antibodies were directed against the intestinal bacteria (24). The immune system may be overreacting to the bacteria themselves, or substances produced by them. Intestinal bacteria may play a part in autoimmune diseases as the immune system first reacts to bacterial antigens and then cross reacts with the body's own cells with a similar protein structures. Sensitization and fermentation types of dysbiosis may go hand in hand, just as deficiency and putrefaction do.