One last point: Because steroids have all these side effects, a lot of abusers will then take other drugs to offset the effect—steroid abuse causes you to grow man-boobs, so people take another drug to mitigate those side effects. Guys who take steroids often also take augmenting drugs to decrease estrogen production or to improve athletic performance even further, like human growth hormone, insulin-like growth factor 1, insulin, erythropoietin, stimulants, diuretics, levothyroxine, and/or gamma-hydroxybutyrate, according to the study in FP Essentials . That means on top of all these side effects of steroids, most abusers are also looking at a whole separate list of effects from their peripheral drug habits.
A very typical case of severe cholestasis due to anabolic steroid use. Because the steroids were being used without medical supervision, the dose and actual duration of use of each preparation was unclear, but cholestasis usually arises within 4 to 12 weeks of starting a C-17 alkylated androgenic steroid. The jaundice can be severe and prolonged and accompanied by severe pruritus and marked weight loss. The serum enzymes are typically minimally elevated except for a short period immediately after stopping therapy. The pattern of enzyme elevations can be hepatocellular, cholestatic or mixed. Liver biopsy shows a “bland” cholestasis with minimal inflammation and hepatocellular necrosis. Ma Huang has also been implicated in cases of drug induced liver injury, but is associated with an acute hepatocellular pattern of injury.